Efficacy and Safety of Intensified Versus Standard Prophylactic Anticoagulation Therapy in Patients With Coronavirus Disease 2019: A Systematic Review and Meta-Analysis

Figures

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  Figure 1.. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram. Abbreviations: COVID-19, coronavirus disease 2019; NIH, National Institutes of Health; OPA, Office of Portfolio Analysis; RCT, randomized controlled trial; WHO, World Health Organization.

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  Figure 2.. A, Mortality with intensified vs prophylactic anticoagulation. The single outpatient trial [27] was excluded from the forest plot because of no mortality events. B, Venous thromboembolism with intensified vs prophylactic anticoagulation. The single outpatient trial [27] was excluded from the forest plot because of no mortality events. Two other trials were excluded because venous thromboembolic events were not captured as outcomes [30, 31]. C, Major bleeding with intensified vs prophylactic anticoagulation. Abbreviations: CI, confidence interval; REML, restricted maximum likelihood.

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  Figure 3.. Subgroup analysis of mortality with intensified vs prophylactic anticoagulation, by clinical setting (intensive care unit [ICU] vs hospitalized non-ICU) (A) and by dose of intensified anticoagulation (therapeutic vs intermediate) (B). The single outpatient trial [27] was excluded from the forest plot because of no mortality events. Two other trials were excluded because venous thromboembolic events were not captured as outcomes [30, 31]. Abbreviations: CI, confidence interval; ICU, intensive care unit; REML, restricted maximum likelihood.

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  Figure 4.. Venous thrombosis with intensified vs prophylactic anticoagulation, by stratified by clinical setting (intensive care unit [ICU] vs hospitalized non-ICU). The single outpatient trial [27] was excluded from the forest plot because of no mortality events. Two other trials were excluded because venous thromboembolic events were not captured as outcomes [30, 31]. Abbreviations: CI, confidence interval; ICU, intensive care unit; REML, restricted maximum likelihood.

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  Figure 5.. Subgroup analysis of major bleeding with intensified vs prophylactic anticoagulation, by clinical setting (intensive care unit [ICU] vs hospitalized non-ICU) (A) and by dose of intensified anticoagulation (therapeutic vs intermediate) (B). Abbreviations: CI, confidence interval; ICU, intensive care unit; REML, restricted maximum likelihood.