What does this research mean for the field?

Subjective surgical success after primary uterovaginal prolapse repair is predominantly defined by a single item on the PFDI-20 (absence of a vaginal bulge symptom), while validated thresholds like MCID and PASS are rarely applied. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate how subjective surgical success is defined using the Pelvic Floor Distress Inventory (PFDI-20) and its components following primary uterovaginal prolapse repair.

September 14, 2026International Urogynecology JournalOpen Access

How is Subjective Surgical Success Defined Using the Pelvic Floor Distress Inventory (PFDI-20) After Primary Uterovaginal Prolapse Repair? A Systematic Review and Consensus Statements from the U-POP & LUTD 2026 Global Consensus Conference

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Authors

ARAlessandro Ferdinando Ruffolo MDMarisa Nhat-Quynh Duong LCLaura Cheng

Discussion

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Overview

Systematic review reveals variable PFDI-20 definitions of subjective surgical success in women with uterovaginal prolapse, highlighting the need for standardized clinical thresholds.

Key Points

To evaluate how subjective surgical success is defined using the Pelvic Floor Distress Inventory (PFDI-20) and its components following primary uterovaginal prolapse repair.
Conducted a systematic review (PROSPERO CRD420251171050) across MEDLINE, EMBASE, and ClinicalTrials.gov from inception through December 8, 2025, following PRISMA guidelines.
Included 28 English-language studies evaluating 4,196 women undergoing primary uterovaginal prolapse repair that reported PFDI-20- or POPDI-6-based surgical success criteria, assessing evidence certainty using GRADE.
Subjective surgical success was most frequently defined as the absence of vaginal bulge symptoms based on a negative response to PFDI-20 question 3 in 21 of 28 studies.
Alternative definitions included question 3 combined with other items, a negative POPDI-6 subscale, or a statistically significant change in total PFDI-20 scores.
Only 1 of 28 studies applied a minimal clinically important difference (MCID), and zero studies implemented a patient acceptable symptom state (PASS).

Cite This Study

Ruffolo et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b2e10926e14a848b1699 https://doi.org/10.1007/s00192-026-06896-x

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September 14, 2026International Urogynecology JournalOpen Access

How is Subjective Surgical Success Defined Using the Pelvic Floor Distress Inventory (PFDI-20) After Primary Uterovaginal Prolapse Repair? A Systematic Review and Consensus Statements from the U-POP & LUTD 2026 Global Consensus Conference

View Full Paper

Ask AI

Bookmark

Authors

ARAlessandro Ferdinando Ruffolo MDMarisa Nhat-Quynh Duong LCLaura Cheng

Discussion

Member takes

Overview

Systematic review reveals variable PFDI-20 definitions of subjective surgical success in women with uterovaginal prolapse, highlighting the need for standardized clinical thresholds.

Key Points

To evaluate how subjective surgical success is defined using the Pelvic Floor Distress Inventory (PFDI-20) and its components following primary uterovaginal prolapse repair.
Conducted a systematic review (PROSPERO CRD420251171050) across MEDLINE, EMBASE, and ClinicalTrials.gov from inception through December 8, 2025, following PRISMA guidelines.
Included 28 English-language studies evaluating 4,196 women undergoing primary uterovaginal prolapse repair that reported PFDI-20- or POPDI-6-based surgical success criteria, assessing evidence certainty using GRADE.
Subjective surgical success was most frequently defined as the absence of vaginal bulge symptoms based on a negative response to PFDI-20 question 3 in 21 of 28 studies.
Alternative definitions included question 3 combined with other items, a negative POPDI-6 subscale, or a statistically significant change in total PFDI-20 scores.
Only 1 of 28 studies applied a minimal clinically important difference (MCID), and zero studies implemented a patient acceptable symptom state (PASS).

Cite This Study

Ruffolo et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b2e10926e14a848b1699 https://doi.org/10.1007/s00192-026-06896-x

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