PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
September 14, 2026Journal of Alzheimer s Disease

Evaluation of the NIH Toolbox Odor Identification Test in African American older adults with and without amnestic mild cognitive impairment

View Full Paper
Ask AI
Bookmark
Share

Authors

BEBerivan EceBGBruno GiordaniFGFelicia C. Goldstein

Discussion

Loading...

Member takes

Overview

Cross-sectional study demonstrates modest diagnostic accuracy of odor identification in older African American adults, suggesting its utility as a rapid screening tool for cognitive impairment.

Key Points

  • To evaluate the diagnostic discrimination and exploratory utility of the NIH Toolbox Odor Identification Test in distinguishing healthy aging from amnestic mild cognitive impairment in older African American adults.
  • Assessed 93 cognitively healthy older adults (mean age 73.85 years) and 52 individuals with amnestic mild cognitive impairment (mean age 74.37 years).
  • Analyzed odor identification scores using two-way ANCOVA adjusting for age and education, with diagnostic accuracy evaluated via Receiver Operating Characteristic analysis and Youden index optimization.
  • Examined APOE ε4 genetic carrier status in an exploratory subset comprising 64.8% of the cohort.
  • Healthy agers achieved significantly higher odor identification scores than those with amnestic mild cognitive impairment (p = 0.019), and female participants outperformed males (p = 0.031).
  • Receiver Operating Characteristic analysis revealed modest discrimination with an Area Under the Curve of 0.626 (p = 0.010); a cut-off score of 5.5 yielded 76.3% specificity and 40.4% sensitivity.
  • Odor identification scores showed no significant differences based on APOE ε4 status or diagnosis-by-sex interaction effects.

Cite This Study

Ece et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b2f70926e14a848b196dhttps://doi.org/10.1177/13872877261483176
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Remote olfactory assessment using the NIH Toolbox Odor Identification test and the brain health registry2024 · 1 citations
  2. 2Identification of amnestic mild cognitive impairment among Black and White community-dwelling older adults using NIH Toolbox Cognition tablet battery2024 · 3 citations
  3. 3AROMHA Brain Health Test: A Remote Olfactory Assessment as a Screen for Cognitive Impairment2024 · 3 citations
  4. 4Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer’s disease2024 · 2 citations
  5. 5Olfactory Testing With Focus on Odor Identification for Early Detection of Alzheimer’s Disease in Mild Cognitive Impairment2025