Key result
Newly diagnosed CAD is linked to ~42% lower insulin sensitivity versus healthy controls.
Why the study?
Whether insulin resistance is present in CAD at diagnosis and how it relates to other cardiovascular risk factors required elucidation.
Is insulin resistance more prevalent in patients with newly diagnosed coronary artery disease compared to healthy controls?
Case-Control (n=55)
Is insulin resistance more prevalent in patients with newly diagnosed coronary artery disease compared to healthy controls?
Absolute Event Rate: 29.23% vs 50.33%
p-value: p=< 0.001
Insulin resistance is highly prevalent in newly diagnosed CAD patients without known metabolic disorders, suggesting it plays an early role in coronary atherosclerosis.
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May indicate early insulin resistance in new CAD; hypothesis-generating and needs prospective confirmation before clinical adoption.
drola et al. (1996) conducted a case-control in Coronary artery disease (n=55). Coronary artery disease vs. Healthy subjects was evaluated on Insulin sensitivity index (ISI) (p=< 0.001). Newly diagnosed CAD patients had a significantly lower insulin sensitivity index compared to healthy controls (29.23 vs 50.33 dl/kg per min, P < 0.001), with insulin resistance present in 82.5%.
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