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Review demonstrates strategies for designing metal ligand architectures in asymmetric catalysis, highlighting pathways toward sustainable synthesis and enhanced enantioselectivity.
From the asymmetric metal complex catalyzed reaction tuning electronic characteristics, managing steric environments, and designing the ligand backbone to encourage electron transfer, stabilized the catalyst, and regulate metal redox states some methods are used to improve the performance of ligand-based catalysts. Developing novel catalysts with adjustable electrical characteristics and increased stiffness in order to increase enantioselectivity. Sustainable synthesis by using eco-friendly oxidants, solvents, and reaction conditions. Chiral catalysts can be used for more difficult organic synthesis reactions. Creating asymmetric catalysts of the future by applying mechanistic knowledge and computational chemistry.
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Patel et al. (2026) studied this question.
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