Methodological study demonstrates standardized metagenomic community state classification in vaginal microbiomes, indicating enhanced precision for tracking health risks.
Metagenomic community state types (mgCSTs) capture within-species genetic and functional diversity and community structure of the vaginal microbiome, enabling precise links between microbiome composition, function, and health-related risk. VISTA, the V aginal I nference of S ubspecies and T yping A lgorithm, is a two-step classifier that assigns mgCSTs to vaginal metagenomes, providing standardized, scalable classifications.
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Holm et al. (2026) studied this question.
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