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Theoretical modeling reveals non-invasive biological entropy reversal in aged cellular states, suggesting a mathematical framework for cellular restoration.
Conventional biological paradigms view cellular aging as an irreversible accumulation of molecular damage. In this paper, we reframe biological systems as open, far-from-equilibrium thermodynamic networks governed by Rough Operator Algebra (ROA) and Phase Space Composite Torsion. We prove that aging corresponds to the accumulation of non-commutative metabolic residuals that deform the phase space topology. By defining a pristine biological information template I_template via the maximal biological coherence eigenvalue Λ_opt and the zero-torsion baseline T_0, we formulate a topological phase transition equation that forces the macro-collapse of aged cellular states back into their youthful attractor, achieving non-invasive biological entropy reversal.
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Seonggil Lee (2026) studied this question.
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