What does this research mean for the field?

Lower baseline body mass index is independently associated with a greater long-term decline in physical activity in patients with chronic obstructive pulmonary disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify baseline clinical, functional, and anthropometric characteristics associated with long-term changes in accelerometer-measured physical activity and sedentary behavior in patients with stable COPD.

September 14, 2026Journal of Clinical MedicineOpen Access

Low Body Mass Index Is Associated with a Long-Term Decline in Accelerometer-Measured Physical Activity in Patients with COPD: An Exploratory Analysis of Participants Co-Enrolled in Two Prospective Cohort Studies

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Authors

YMYusuke MurakamiHidaka Hospital YMYoshiaki MinakataKihoku hospital YTYasushi TanimotoOkayama Medical Center

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Implication

Cohort study reveals baseline low body mass index predicts long-term physical activity decline in COPD patients, indicating nutritional status influences mobility preservation.

Key Points

To identify baseline clinical, functional, and anthropometric characteristics associated with long-term changes in accelerometer-measured physical activity and sedentary behavior in patients with stable COPD.
Retrospectively analyzed data from N=32 Japanese male outpatients with stable COPD co-enrolled in two prospective cohort studies across a median follow-up of 5.0 years.
Assessed 29 baseline clinical parameters alongside physical activity and sedentary behavior tracked via waist-worn triaxial accelerometers and expressed in metabolic equivalents (METs).
Evaluated annualized percentage changes in physical activity metrics using Spearman's rank correlation and multivariable linear regression models adjusted for pulmonary function and desaturation.
Lower baseline body weight, BMI, upper arm circumference, FEV1.0, FEV1.0/FVC, and lowest SpO2 during the 6-minute walk test were significantly correlated with greater annualized physical activity declines.
In multivariable linear regression adjusted for FEV1.0 % predicted and minimum 6-minute walk SpO2, lower BMI remained significantly associated with steeper declines in total physical activity and active time (≥3.0 METs).
Sedentary behavior changes correlated with 6-minute walk SpO2, FEV1.0/FVC, and hemoglobin on bivariate analysis, but multivariable models for sedentary behavior and step count showed no significant associations.

Cite This Study

Murakami et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3660926e14a848b23cd https://doi.org/10.3390/jcm15187038

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Implication

Cohort study reveals baseline low body mass index predicts long-term physical activity decline in COPD patients, indicating nutritional status influences mobility preservation.

Low Body Mass Index Is Associated with a Long-Term Decline in Accelerometer-Measured Physical Activity in Patients with COPD: An Exploratory Analysis of Participants Co-Enrolled in Two Prospective Cohort Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

Low Body Mass Index Is Associated with a Long-Term Decline in Accelerometer-Measured Physical Activity in Patients with COPD: An Exploratory Analysis of Participants Co-Enrolled in Two Prospective Cohort Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

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