Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy

Q: What does this research mean for the field?

Quantitative oculography metrics from advanced eye movement tasks are promising candidate biomarkers for the diagnosis, differentiation, and longitudinal monitoring of progressive supranuclear palsy. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Haoxuan Ouyang; Bo Liu; Qiwei Peng; Zhuoran Ma; Zhicheng Tang; An Chang; MaoYu Liu; Xuebing Cao; Yan Xu; Yun Xia

doi:10.3390/diagnostics16182944

September 11, 2026DiagnosticsOpen Access

Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy

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Key Points

To review the pathophysiological mechanisms of eye movement abnormalities in progressive supranuclear palsy (PSP) and evaluate quantitative oculography as a diagnostic and monitoring biomarker.
Narrative review synthesizing findings from advanced eye movement tasks recorded using quantitative video-oculography (VOG).
Assessment of oculomotor tasks including prosaccades, antisaccades, memory-guided saccades, predictive saccades, overlap saccades, and gap saccades across neurodegenerative cohorts.
Abnormalities across specialized saccadic tasks correspond to distinct pathophysiological deficits in PSP neural pathways.
Quantitative metrics extracted from video-oculography differentiate PSP from Parkinson's disease, multiple system atrophy, corticobasal degeneration, and Alzheimer's disease.
Digital oculomotor parameters successfully discriminate between specific PSP clinical subtypes, supporting their role in differential diagnosis and longitudinal tracking.

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Implication

Review demonstrates quantitative oculography metrics differentiate progressive supranuclear palsy from related neurodegenerative disorders, indicating strong potential for objective biomarkers.

Abstract

Conventional qualitative eye movement examinations may miss subtle abnormalities, complicating early and accurate diagnosis of progressive supranuclear palsy (PSP). Quantitative oculography, represented by video-oculography (VOG), provides an objective digital assessment of eye movements. This review summarizes abnormalities in advanced eye movement tasks in PSP, including prosaccades (ProSs), antisaccades (ASs), memory-guided saccades (MGSs), predictive saccades (PSs), overlap saccades (OSs) and gap saccades (GSs), and considers their underlying pathophysiological mechanisms. Quantitative metrics from these tasks may help distinguish PSP subtypes and PSP from other neurodegenerative diseases, such as Parkinson’s disease (PD), multiple system atrophy (MSA), corticobasal degeneration (CBD) and Alzheimer’s disease (AD). Advanced eye movement measures are therefore promising candidate biomarkers for PSP diagnosis and longitudinal disease monitoring.

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Cite This Study

Ouyang et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3660926e14a848b2578 https://doi.org/10.3390/diagnostics16182944

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Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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