New Approaches to the Synthesis of 6-Amino-4-aryl-5-(4-arylthiazol-2-yl)-2-methoxynicotinonitriles

Reactions of (2E)-3-aryl-2-(4-arylthiazol-2-yl)acrylonitriles, malononitrile, and sodium methoxide or 2-[4-(4-bromophenyl)thiazol-2-yl]acetonitrile, 4-methoxybenzylidenemalononitrile, and potassium hydroxide in methanol proceed to give 6-amino-4-aryl-5-(4-arylthiazol-2-yl)-2-methoxynicotinonitriles in 38–47% yields.