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September 14, 2026Respiratory ResearchOpen Access

Exploratory proteomic analysis of idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis using data-independent acquisition

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Authors

MOMasaki OkamotoTYToyoshi YanagiharaYZYoshiaki Zaizen

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Overview

Comparative proteomic study uncovers distinct protein profiles in patients with interstitial lung diseases, highlighting potential biomarkers for precise diagnosis.

Key Points

  • To identify potential diagnostic biomarkers and clarify divergent pathogenic mechanisms differentiating idiopathic pulmonary fibrosis from fibrotic hypersensitivity pneumonitis.
  • Analyzed formalin-fixed, paraffin-embedded lung tissue specimens from patients with idiopathic pulmonary fibrosis (n = 5), fibrotic hypersensitivity pneumonitis (n = 10), and controls (n = 7) via data-independent acquisition mass spectrometry.
  • Performed gene enrichment, biological pathway, and upstream regulator analyses, validating key findings with public single-cell RNA sequencing data.
  • Quantified 7,939 proteins, demonstrating distinct protein expression profiles in both disease groups compared with control tissues.
  • Proteins upregulated in idiopathic pulmonary fibrosis were predominantly cilium-related and restricted to MUC5AC+ or ciliated epithelial cells, with enrichment in protein glycosylation and fatty acid metabolism.
  • Fibrotic hypersensitivity pneumonitis tissues exhibited prominent upregulation of immune signaling pathways, implicating MAP3K8, SENP2, TEC, and FER as disease-specific upstream regulators.

Cite This Study

Okamoto et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3bf0926e14a848b2dcbhttps://doi.org/10.1186/s12931-026-03903-z
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Also Consider

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  1. 1Plasma proteomics and machine learning deliver non-invasive distinction between fibrotic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis2026
  2. 2C71-09 Proteomic Profiling in Hermansky-Pudlak Syndrome Compared to Primary Ciliary Dyskinesia and Healthy Controls Reveals Elevated Proteins Linked to Pulmonary Fibrosis2026
  3. 3A system biology study of BALF from patients affected by idiopathic pulmonary fibrosis (IPF) and healthy controls2014 · 71 citations
  4. 4Identification of CFH and FHL2 as biomarkers for idiopathic pulmonary fibrosis2024 · 4 citations
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