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August 29, 2014PROTEOMICS - CLINICAL APPLICATIONS

A system biology study of BALF from patients affected by idiopathic pulmonary fibrosis (IPF) and healthy controls

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Population

Patients with idiopathic pulmonary fibrosis (IPF), never-smoker healthy controls, and smoker controls

Design

Other

Authors

CLClaudia LandiEBElena BargagliACAlfonso Carleo

Discussion

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Overview

Should not alter IPF management; hypothesis-generating for RAAS and oxidative stress as targets.

Structured PICO

P
Population
Patients with idiopathic pulmonary fibrosis (IPF), never-smoker healthy controls, and smoker controls
C
Comparator
Never-smoker healthy controls and smoker controls
O
Outcome
Differentially expressed proteins in bronchoalveolar lavage fluid (BALF) and associated functional pathwayssurrogate

Proteomic profiling of BALF in IPF patients identifies key pathways including RAAS and oxidative stress, highlighting potential biomarkers and therapeutic targets.

Cite This Study

Landi et al. (2014) studied this question.

synapsesocial.com/papers/6a72c205ac440176ef2ad680https://doi.org/10.1002/prca.201400001
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