What does this research mean for the field?

Both C-reactive protein (CRP) and procalcitonin (PCT) are effective diagnostic markers for identifying bacterial infection in neonates with respiratory distress, with CRP demonstrating slightly superior overall diagnostic accuracy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the diagnostic performance of serum procalcitonin (PCT) and C-reactive protein (CRP) in identifying bacterial infections among neonates presenting with respiratory distress, and to examine their association with blood culture findings.

September 14, 2026Advances in Clinical Medical ResearchOpen Access

Comparative Performance of Procalcitonin and C-Reactive Protein in Identifying Bacterial Infection Among Neonates With Respiratory Distress

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Authors

SYShivam Yadav ASA.B Singh SYShivi Yadav

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Implication

Observational diagnostic study reveals superior accuracy for C-reactive protein over procalcitonin in neonates with respiratory distress, suggesting improved early detection of bacterial infections.

Key Points

To compare the diagnostic performance of serum procalcitonin (PCT) and C-reactive protein (CRP) in identifying bacterial infections among neonates presenting with respiratory distress, and to examine their association with blood culture findings.
Hospital-based observational diagnostic study involving 60 neonates presenting with respiratory distress, divided into infectious (n=30) and non-infectious (n=30) groups.
Serum PCT and CRP levels were measured and evaluated for sensitivity, specificity, positive predictive value, negative predictive value, overall accuracy, and area under the receiver operating characteristic curve (ROC-AUC).
Mean PCT was significantly elevated in the infectious group compared with the non-infectious group (61.05 ± 50.764 vs. 23.01 ± 42.214 ng/mL; p < 0.001), as was mean CRP (26.39 ± 36.836 vs. 4.97 ± 6.148 mg/dL; p = 0.005).
CRP demonstrated an overall diagnostic accuracy of 83.3% (sensitivity, specificity, PPV, and NPV all 83.3%; AUC = 0.822, p < 0.0001), outperforming PCT, which showed a diagnostic accuracy of 76.7% (AUC = 0.777, p < 0.0001).

Cite This Study

Yadav et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3df0926e14a848b31e2 https://doi.org/10.5281/zenodo.22726004

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Implication

Observational diagnostic study reveals superior accuracy for C-reactive protein over procalcitonin in neonates with respiratory distress, suggesting improved early detection of bacterial infections.

Comparative Performance of Procalcitonin and C-Reactive Protein in Identifying Bacterial Infection Among Neonates With Respiratory Distress

Discussion

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Implication

Key Points

Cite This Study

Comparative Performance of Procalcitonin and C-Reactive Protein in Identifying Bacterial Infection Among Neonates With Respiratory Distress

Discussion

Member takes

Implication

Key Points

Cite This Study

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