10° Celsius Static Storage in Deceased Donor Organ Transplantation: A Narrative Review

Purpose of Review Static storage at 10 °C for solid organ transplant has recently emerged as a promising alternative technology to conventional preservation on ice. This narrative review summarizes the preclinical and clinical evidence supporting 10 °C storage in heart, lung, liver, and kidney transplantation, and examines the biochemical mechanisms that may underlie its benefits. Using a narrative review approach informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis– Scoping Review guidelines (PRISMA-ScR), we identified 597 peer-reviewed studies from major databases including PubMed, Embase, Web of Science, and Scopus that evaluated preclinical and clinical outcomes in transplantation following donor organ storage at 10 °C. Recent Findings Available preclinical and early clinical evidence suggests that static storage at 10 °C may help to preserve mitochondrial function, limit ischemia-reperfusion injury and support graft performance comparable to or better than traditional ice storage, highlighting its potential as a practical and cost-effective storage technology for organ transplantation. These results are more applicable to heart and lung storage, where there are higher quality data and studies, compared to liver and kidney storage. Summary Definitive conclusions regarding the role of 10°C static storage in organ transplantation await well-designed randomized clinical trials capable of providing the highest quality evidence.