Late-Onset or Late-Recognized? A Teaching Point From an Elderly X-Linked CGD Carrier

Q: What does this research mean for the field?

Symptoms in elderly X-linked chronic granulomatous disease (CGD) carriers may represent late recognition rather than true late-onset disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Nezihe Köker; Ercan Yılmaz; Erdem Topal; Mustafa Yavuz Köker

doi:10.1093/cid/ciag563

September 11, 2026Clinical Infectious DiseasesOpen Access

Late-Onset or Late-Recognized? A Teaching Point From an Elderly X-Linked CGD Carrier

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Key Points

To investigate whether clinical features in an elderly carrier of X-linked chronic granulomatous disease reflect late disease onset or delayed diagnostic recognition.
Clinical and diagnostic evaluation of an elderly female carrier of X-linked chronic granulomatous disease.
Identified symptomatic manifestations in an elderly X-linked CGD carrier presenting with long-standing immune-related complications.
Demonstrated that variable X-chromosome inactivation can produce disease manifestations that are easily misclassified as late-onset rather than belatedly recognized.

Implication

Case report uncovers delayed diagnosis in an elderly X-linked CGD carrier, highlighting the need for clinical vigilance in female carriers.

Abstract

Nezihe Köker Özer, Ercan Yılmaz, Erdem Topal, Mustafa Yavuz Köker; Late-Onset or Late-Recognized? A Teaching Point From an Elderly X-Linked CGD Carrier, Cl

Discussion

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Cite This Study

Köker et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3ee0926e14a848b335a https://doi.org/10.1093/cid/ciag563

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Late-Onset or Late-Recognized? A Teaching Point From an Elderly X-Linked CGD Carrier

Key Points

Implication

Abstract

Discussion

Cite This Study

Late-Onset or Late-Recognized? A Teaching Point From an Elderly X-Linked CGD Carrier

Key Points

Implication

Abstract

Discussion

Cite This Study

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