What does this research mean for the field?

The cellular and in vivo fate of DNA nanostructures is critically determined by intrinsic structural parameters and extrinsic physiological factors, which must be optimized to overcome translational barriers in biomedical applications. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To provide a comprehensive synthesis of how structural designs and physiological environments govern the cellular processing, biodistribution, and in vivo fate of DNA nanostructures.

September 14, 2026

Cellular and In Vivo Fate of DNA Nanostructures.

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To provide a comprehensive synthesis of how structural designs and physiological environments govern the cellular processing, biodistribution, and in vivo fate of DNA nanostructures.
Categorized representative DNA nanostructure architectures into three distinct classes based on self-assembly strategies driven by complementary base pairing.
Evaluated the impact of intrinsic parameters (size, morphology, surface functionalization) and extrinsic factors (enzymes, pH, temperature) on biological longevity.
Surveyed dynamic monitoring techniques—including fluorescence imaging, radiolabeling, and MRI—tracking absorption, biodistribution, cellular uptake, clearance, and immunogenicity.
Structural parameters such as particle geometry, dimensions, and surface passivation directly govern cellular internalization routes, organ biodistribution, and renal or hepatic clearance rates.
Physiological barriers, especially rapid degradation by circulating nucleases and clearance via the reticuloendothelial system, pose major challenges to in vivo bioavailability.
Translational hurdles can be mitigated through environmentally responsive assemblies, targeted surface shielding, and theranostic integration to enhance therapeutic payload delivery.

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Implication

Review reveals how intrinsic features govern DNA nanostructure clearance and uptake in biological systems, highlighting critical design rules for nanomedicine.

Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b42d0926e14a848b3cbf https://doi.org/10.1021/acsami.6c09876

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Implication

Review reveals how intrinsic features govern DNA nanostructure clearance and uptake in biological systems, highlighting critical design rules for nanomedicine.

Cellular and In Vivo Fate of DNA Nanostructures.

Key Points

Discussion

Implication

Cite This Study

Cellular and In Vivo Fate of DNA Nanostructures.

Key Points

Discussion

Implication

Cite This Study

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