Key result
LV perfusion heterogeneity drives differences in substrate uptake and energy turnover as a novel homeostatic mechanism.
Highlights the physiological importance of spatial heterogeneity in myocardial perfusion and its link to local protein expression.
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Regional perfusion heterogeneity may shape local myocardial biology; leaves open its relevance to clinical HF phenotypes or targeted interventions.
Ulrich K. M. Decking (2002) studied this question. Spatial heterogeneity in left ventricular myocardial perfusion drives differences in substrate uptake, energy turnover, and protein expression, forming a novel homeostatic mechanism.
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