Key result
Local capillary membrane permeability-surface area products increased almost in proportion with local myocardial blood flow, challenging the assumption of uniform membrane conductances.
Population
5 dogs running on a sloped treadmill
Design
Preclinical
Follow-up
100 seconds
Authors
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Challenges uniform conductance assumptions in myocardial perfusion models; leaves open translation to human physiology or imaging.
In a canine model, local capillary permeability-surface area products in the myocardium increase proportionally with local blood flow, indicating that current models assuming uniform membrane conductances need revision.
Caldwell et al. (1994) studied normal heart (n=5). tracer microspheres and [131I]iodophenylpentadecanoic acid (IPPA) injection was evaluated on capillary membrane permeability-surface area products (PSc). Local capillary membrane permeability-surface area products increased almost in proportion with local myocardial blood flow, challenging the assumption of uniform membrane conductances.
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