What does this research mean for the field?

In the myocardium, blood content exhibits significant transmural and base-apex gradients, and only a fraction of available capillaries are perfused at rest, with uniform plasma and red cell distribution indicating no role for plasma skimming in increasing oxygen delivery to inner layers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1964American Journal of Physiology-Legacy Content

Number and distribution of capillaries as determinants of myocardial oxygen tension

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Population

Dogs (myocardium)

Design

Preclinical

Authors

WMWayne W. MyersUniversity of Rochester CHCarl R. HonigUniversity of Rochester

Discussion

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Implication

Supports heterogeneous capillary recruitment in resting myocardium; hypothesis-generating for oxygen models pending human validation.

Structured PICO

Population

Dogs (myocardium)

Intervention

Measurement of blood content using I131-labeled albumin and Cr51O4-labeled red cells

Outcome

Blood content per gram of tissue and ratio of I131 to Cr51O4 distributionssurrogate

This preclinical study demonstrates transmural gradients in myocardial blood content and suggests that only a fraction of available capillaries are perfused at rest.

Cite This Study

Myers et al. (1964) studied this question.

synapsesocial.com/papers/6a1c18124ebd09f3dfa96e6b https://doi.org/10.1152/ajplegacy.1964.207.3.653

Topics

Sermorelin

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Number and distribution of capillaries as determinants of myocardial oxygen tension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Number and distribution of capillaries as determinants of myocardial oxygen tension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider