Key result
In isolated dog hearts, capillary permeability-surface area products for potassium increased at higher plasma flows, while cell permeability was calculated to be low compared to capillary permeability.
Population
15 isolated canine heart preparations
Design
Preclinical
Follow-up
up to 60 min
Authors
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Findings in isolated dog hearts should not change practice; leaves open relative capillary and sarcolemmal roles in intact myocardium.
In isolated dog hearts, cell permeability to potassium is low compared to capillary permeability, with the sarcolemmal permeability-surface area product being about 50% of the capillary product.
Tancredi et al. (1975) studied this question. Pulse injections of 42KCl and 131I-labeled albumin was evaluated on Maximal fractional extractions (Emax) and capillary permeability-surface area products (PScap) for 42K+. In isolated dog hearts, capillary permeability-surface area products for potassium increased at higher plasma flows, while cell permeability was calculated to be low compared to capillary permeability.