What question did this study set out to answer?

This research investigates how lipid-insoluble molecules exchange across heart capillaries.

May 1, 1969The Journal of PhysiologyOpen Access

Heart capillary permeability to lipid‐insoluble molecules

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Population

Isolated, beating dog hearts perfused with blood

Design

Preclinical

Authors

OÁOsvaldo ÁlvarezUniversity of Chile DYD. L. YudilevichKing's College London

Discussion

Member takes

Implication

May guide microvascular models in myocardium; leaves open human translation from canine pore data.

Key Points

This research investigates how lipid-insoluble molecules exchange across heart capillaries.
Isolated, beating dog hearts were perfused with blood to measure transcapillary exchange.
Indicator diffusion technique involved rapid arterial injection and venous outflow sample collection.
Capillary permeability constants were calculated from fractional extraction values at varying blood flow rates.
E for [3H]water was highest at 0.90 +/- 0.3, remaining constant with flow.
Average permeability constants for inulin, sucrose, glucose, glycerol, and urea were found to be between 0.27 and 3.1 x 10(5) cm/sec.
The study suggests capillary pores must be larger than 80-100 A diameter based on permeability measurements.

Structured PICO

Population

Isolated, beating dog hearts perfused with blood

Intervention

Arterial injection of a mixture containing diffusible and non-diffusible molecules ([(3)H]water, (22)Na, (86)Rb, (36)Cl, [(14)C]urea, [(3)H]glycerol, [(3)H]glucose, [(14)C]sucrose and [(3)H]inulin)

Outcome

Transcapillary exchange (fractional extraction, E, and capillary permeability constant, P) of various moleculessurrogate

The study demonstrates that capillary permeability to lipid-insoluble molecules in the dog heart suggests the presence of pores larger than 80-100 A diameter, likely corresponding to intercellular slits.

Cite This Study

Álvarez et al. (1969) studied this question.

synapsesocial.com/papers/6a0d02c3a064aa35e1cc8ef2 https://doi.org/10.1113/jphysiol.1969.sp008794

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Heart capillary permeability to lipid‐insoluble molecules

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Heart capillary permeability to lipid‐insoluble molecules

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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