Key result
Potassium efflux in the dog heart in situ averaged 0.68 mEq K+/kg/min at 130 beats/min, with 1.65 µEq K+/kg exchanged per beat above the estimated resting flux.
Population
Dog heart in situ model
Design
Preclinical
Authors
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Coronary flow and pressure minimally affect potassium efflux in canine hearts; leaves open relevance to human ischemia or arrhythmias.
This preclinical study quantifies transmembrane potassium fluxes in the dog heart in situ, demonstrating the relationship between heart rate and potassium exchange.
Grupp et al. (1963) studied Dog heart in situ. Coronary perfusion was evaluated on Transmembrane fluxes of potassium. Potassium efflux in the dog heart in situ averaged 0.68 mEq K+/kg/min at 130 beats/min, with 1.65 µEq K+/kg exchanged per beat above the estimated resting flux.
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