March 1, 1968The Journal of PhysiologyOpen Access

The efflux of potassium, sodium, chloride, calcium and sulphate ions and of sorbitol and glycerol during the cardiac cycle in frog's ventricle

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Population

Frog's ventricles (superfused and distended preparations)

Comparison

Measurement of ion and molecule efflux during… vs Quiescent ventricles; calcium-free solutions

Design

Preclinical

Authors

JLJ. F. LambAndrews University JMJohn A. S. McGuiganPennsylvania State University

Discussion

Member takes

Implication

Mechanical distortion may artifactually alter measured potassium fluxes during contraction; leaves open true membrane currents in intact mammalian hearts.

Structured PICO

Population

Frog's ventricles (superfused and distended preparations)

Intervention

Measurement of ion and molecule efflux during the cardiac cycle, including effects of contraction and ouabain poisoning

Comparator

Quiescent ventricles; calcium-free solutions

Outcome

Efflux and influx of potassium, sodium, chloride, calcium, sulphate, sorbitol, and glycerolsurrogate

Mechanical distortion during cardiac contraction in frog ventricles significantly alters the measured efflux of ions, complicating the assessment of true membrane fluxes during the action potential.

Limitations

Ion movements during the long cardiac action potential cannot easily be measured because of mechanical artifacts.

Cite This Study

Lamb et al. (1968) studied this question.

synapsesocial.com/papers/6a883695ab77196d53aa71ec https://doi.org/10.1113/jphysiol.1968.sp008459

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March 1, 1968The Journal of PhysiologyOpen Access

The efflux of potassium, sodium, chloride, calcium and sulphate ions and of sorbitol and glycerol during the cardiac cycle in frog's ventricle

View Full Paper

Ask AI

Bookmark

Population

Frog's ventricles (superfused and distended preparations)

Comparison

Measurement of ion and molecule efflux during… vs Quiescent ventricles; calcium-free solutions

Design

Preclinical

Authors

JLJ. F. LambAndrews University JMJohn A. S. McGuiganPennsylvania State University

Discussion

Member takes

Implication

Mechanical distortion may artifactually alter measured potassium fluxes during contraction; leaves open true membrane currents in intact mammalian hearts.

Structured PICO

Population

Frog's ventricles (superfused and distended preparations)

Intervention

Measurement of ion and molecule efflux during the cardiac cycle, including effects of contraction and ouabain poisoning

Comparator

Quiescent ventricles; calcium-free solutions

Outcome

Efflux and influx of potassium, sodium, chloride, calcium, sulphate, sorbitol, and glycerolsurrogate

Mechanical distortion during cardiac contraction in frog ventricles significantly alters the measured efflux of ions, complicating the assessment of true membrane fluxes during the action potential.

Limitations

Ion movements during the long cardiac action potential cannot easily be measured because of mechanical artifacts.

Cite This Study

Lamb et al. (1968) studied this question.

synapsesocial.com/papers/6a883695ab77196d53aa71ec https://doi.org/10.1113/jphysiol.1968.sp008459

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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