Key result
Application of voltage clamp pulses to frog ventricular strips caused temporary changes in extracellular K concentration, with the N-shaped steady state current-voltage relation mainly reflecting K current voltage dependency.
This preclinical study demonstrates that post-clamp after-potentials reliably estimate extracellular potassium accumulation in frog ventricular muscle, reflecting the voltage dependency of potassium currents.
No takes yet. Share an insight, caveat, or question.
No direct clinical implications from frog data; leaves open K current mechanisms in mammalian hearts.
Cleemann et al. (1979) studied Extracellular potassium accumulation in ventricular muscle. Voltage clamp pulses was evaluated on Extracellular K concentration changes. Application of voltage clamp pulses to frog ventricular strips caused temporary changes in extracellular K concentration, with the N-shaped steady state current-voltage relation mainly reflecting K current voltage dependency.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: