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August 1, 1962American Journal of Physiology-Legacy Content

Phasic efflux of potassium from frog ventricle

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Population

Perfused strips of frog ventricle

Design

Preclinical

Authors

VLVictor LorberUniversity of MinnesotaJWJohn L. WalkerTexas State UniversityEGErnest A. GreeneUniversity of Minnesota

Discussion

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Implication

Supports phasic K efflux with diminished conductance in frog ventricle; leaves open translation to mammalian cardiac electrophysiology.

Structured PICO

P
Population
Perfused strips of frog ventricle
I
Intervention
Perfusion with K-free Ringer's and varying levels of potassium in the perfusion medium
O
Outcome
Phasic efflux of K42 during the cardiac cycle and action potentialsurrogate

Demonstrates that potassium efflux increases during the cardiac action potential in frog ventricle, but with diminished potassium conductance.

Cite This Study

Lorber et al. (1962) studied this question.

synapsesocial.com/papers/6a91748c9547ae2b66afa320https://doi.org/10.1152/ajplegacy.1962.203.2.253
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The efflux of potassium, sodium, chloride, calcium and sulphate ions and of sorbitol and glycerol during the cardiac cycle in frog's ventricle1968 · 15 citations
  2. 2Potassium efflux in heart muscle during activity: extracellular accumulation and its implications.1978 · 114 citations
  3. 3Potassium influx in the frog atrium during the cardiac cycle.1975
  4. 4Extracellular potassium accumulation in voltage‐clamped frog ventricular muscle.1979 · 34 citations
  5. 5Potassium currents in frog ventricular muscle: evidence from voltage clamp currents and extracellular K accumulation.1979 · 50 citations