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June 1, 1960American Journal of Physiology-Legacy Content

Potassium flux in the isolated perfused rabbit heart

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Population

isolated, perfused rabbit heart model

Design

Preclinical

Authors

EHEdward W. HumphreyUniversity of MinnesotaJJJohn A. JohnsonInstitute for Energy Technology

Discussion

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Implication

Hypothesis-generating for cardiac K+ compartmentalization; leaves open translation to human electrophysiology.

Structured PICO

P
Population
isolated, perfused rabbit heart model
I
Intervention
varying heart rate (100 to 200 beats/min), extracellular potassium concentration, and temperature
O
Outcome
exchange kinetics of potassium (potassium flux)surrogate

This preclinical study demonstrates that intracellular potassium in the rabbit heart exists in multiple compartments and that potassium flux activation energy is dependent on extracellular potassium concentration.

Cite This Study

Humphrey et al. (1960) studied this question.

synapsesocial.com/papers/6a91748c9547ae2b66afa322https://doi.org/10.1152/ajplegacy.1960.198.6.1217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potassium efflux from isolated rabbit heart into a potassium-free solution1961 · 1 citations
  2. 2Potassium Exchange in the Dog Heart in Situ1963 · 8 citations
  3. 3Phasic efflux of potassium from frog ventricle1962 · 16 citations
  4. 4The efflux of potassium, sodium, chloride, calcium and sulphate ions and of sorbitol and glycerol during the cardiac cycle in frog's ventricle1968 · 15 citations
  5. 5Potassium, sodium, and iodide transcapillary exchange in the dog heart1965 · 30 citations