Key result
Transcellular sodium exchange in the isolated normal dog heart was 0.04 mEq/kg/beat, supporting sodium influx during the spike potential and a membrane capacity of about 10 µf/cm2.
Population
Isolated normal dog heart
Design
Preclinical
Authors
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Baseline sodium flux data from isolated canine hearts informs membrane models; leaves open translation to human disease.
Demonstrates transcellular sodium exchange of 0.04 mEq/kg/beat in isolated dog hearts, supporting sodium influx during the spike potential.
Conn et al. (1959) studied this question. Transcellular sodium exchange in the isolated normal dog heart was 0.04 mEq/kg/beat, supporting sodium influx during the spike potential and a membrane capacity of about 10 µf/cm2.
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