April 1, 1985Journal of Biological ChemistryOpen Access

Demonstration of a Na+/H+ exchange activity in purified canine cardiac sarcolemmal vesicles.

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Population

Purified canine cardiac sarcolemmal membrane vesicles

Design

Preclinical

Authors

SSSteven M. SeilerLock Haven University ECEdward J. CragoeMerck & Co., Inc., Rahway, NJ, USA (United States)LJLarry R. JonesUniversity of Vermont

Discussion

Member takes

Implication

Provides canine vesicle model for Na+/H+ exchange; leaves open translation to human myocardial ion handling or therapy.

Structured PICO

Population

Purified canine cardiac sarcolemmal membrane vesicles

Intervention

Transmembrane H+ and Na+ gradients, and various inhibitors (quinidine, quinacrine, amiloride, amiloride derivatives)

Outcome

Na+/H+ exchange activity (measured by 22Na uptake and H+ transport)surrogate

Demonstrates the presence of a reversible, tightly coupled Na+/H+ exchange mechanism in canine cardiac sarcolemmal vesicles, establishing a useful model for studying myocardial ion transport.

Cite This Study

Seiler et al. (1985) studied this question.

synapsesocial.com/papers/6a911d463ef1f7fbbf3e86d3 https://doi.org/10.1016/s0021-9258(18)89152-9

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Demonstration of a Na+/H+ exchange activity in purified canine cardiac sarcolemmal vesicles.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Demonstration of a Na+/H+ exchange activity in purified canine cardiac sarcolemmal vesicles.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider