Population
Sarcolemmal membrane vesicles isolated from canine ventricular tissue
Design
Preclinical
Authors
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Vesicle data on NCX electrogenicity warrant model revision; leaves open intact-cell stoichiometry and human arrhythmia relevance.
Demonstrates that the cardiac sodium-calcium exchanger is electrogenic, generating a current consistent with a stoichiometry of 3 or more sodium ions per calcium ion.
Reeves et al. (1980) studied this question.
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