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September 1, 1982AJP Cell Physiology

Stimulation of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by proteinase pretreatment

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Population

Purified canine cardiac sarcolemmal vesicles

Comparison

Pretreatment with a serine or thiol proteinase vs Untreated vesicles

Design

Preclinical

Authors

KPKenneth D. PhilipsonElectrophysiologyANA Y NishimotoAmerican Heart Association

Discussion

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Implication

May inform Na+-Ca2+ exchanger regulation in vesicles; leaves open relevance to intact myocardium or clinical translation.

Structured PICO

P
Population
Purified canine cardiac sarcolemmal vesicles
I
Intervention
Pretreatment with a serine or thiol proteinase
C
Comparator
Untreated vesicles (implied by baseline comparisons)
O
Outcome
Na+-Ca2+ exchange activity (Km for Ca2+ and Vmax for Na+i-dependent Ca2+ influx)surrogate

Proteinase pretreatment significantly stimulates Na+-Ca2+ exchange activity in canine cardiac sarcolemmal vesicles by increasing calcium affinity and maximal transport rate.

Cite This Study

Philipson et al. (1982) studied this question.

synapsesocial.com/papers/6a858e59581d4f62e2d5a9d1https://doi.org/10.1152/ajpcell.1982.243.3.c191
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The dependence of calcium efflux from cardiac muscle on temperature and external ion composition1968 · 1,025 citations
  2. 2The effect of substances releasing intracellular calcium ions on sodium‐dependent calcium efflux from guinea‐pig auricles.1975 · 159 citations
  3. 3Effects of pH on Na+-Ca2+ exchange in canine cardiac sarcolemmal vesicles.1982 · 246 citations
  4. 4Sodium-Calcium Exchange Activity Generates a Current in Cardiac Membrane Vesicles1980 · 183 citations
  5. 5PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,728 citations