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April 1, 1981Journal of Biological ChemistryOpen Access

Efflux of Ca2+ from cardiac sarcolemmal vesicles. Influence of external Ca2+ and Na+.

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Population

Highly purified sarcolemmal vesicles isolated from dog ventricles

Comparison

Exposure to external Na+ and Ca2+ vs Varying concentrations or absence of external ions

Design

Preclinical

Authors

KPKenneth D. PhilipsonElectrophysiologyANA Y NishimotoAmerican Heart Association

Discussion

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Implication

Informs kinetic models of cardiac Ca2+ handling; leaves open physiologic relevance in intact myocytes or human disease.

Structured PICO

P
Population
Highly purified sarcolemmal vesicles isolated from dog ventricles
I
Intervention
Exposure to external Na+ and Ca2+ (and other monovalent cations like K+, Li+, choline+)
C
Comparator
Varying concentrations or absence of external ions
O
Outcome
Ca2+ effluxsurrogate

External Na+ and Ca2+ compete for binding sites to induce Ca2+ efflux in cardiac sarcolemmal vesicles, providing mechanistic insights into cardiac calcium handling.

Cite This Study

Philipson et al. (1981) studied this question.

synapsesocial.com/papers/6a7239acac440176ef2a92edhttps://doi.org/10.1016/s0021-9258(19)69511-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The dependence of calcium efflux from cardiac muscle on temperature and external ion composition1968 · 1,025 citations
  2. 2Na+-Ca2+ exchange is affected by membrane potential in cardiac sarcolemmal vesicles.1980 · 113 citations
  3. 3The effect of sodium, calcium and metabolic inhibitors on calcium efflux from goldfish heart ventricles.1978 · 34 citations
  4. 4Sodium-Calcium Exchange Activity Generates a Current in Cardiac Membrane Vesicles1980 · 183 citations
  5. 5The effect of substances releasing intracellular calcium ions on sodium‐dependent calcium efflux from guinea‐pig auricles.1975 · 159 citations