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January 1, 1984Journal of Biological ChemistryOpen Access

Stimulation of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by phospholipase D.

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Why the study?

Does phospholipase D treatment stimulate Na+-Ca2+ exchange in canine cardiac sarcolemmal vesicles?

Population

Canine cardiac sarcolemmal vesicles

Comparison

Treatment with phospholipase D vs Untreated vesicles (implied baseline/control)

Design

Preclinical

Authors

KPKenneth D. PhilipsonElectrophysiologyANA Y NishimotoAmerican Heart Association

Discussion

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Overview

Phospholipase D boosts Na+-Ca2+ exchange in isolated vesicles; leaves open any role in intact heart or clinical calcium handling.

Structured PICO

Does phospholipase D treatment stimulate Na+-Ca2+ exchange in canine cardiac sarcolemmal vesicles?

P
Population
Canine cardiac sarcolemmal vesicles
I
Intervention
Treatment with phospholipase D (e.g., 0.4 unit/ml for 20 min at 37 degrees C)
C
Comparator
Untreated vesicles (implied baseline/control)
O
Outcome
Na+-Ca2+ exchange activity (including apparent Km for Ca2+ and Vmax)surrogate

Phospholipase D stimulates Na+-Ca2+ exchange in cardiac sarcolemmal vesicles, likely due to elevated phosphatidic acid levels, supporting the hypothesis that negatively charged phospholipids are important in this exchange.

Cite This Study

Philipson et al. (1984) studied this question.

synapsesocial.com/papers/6a6f7580febe604dd7086150https://doi.org/10.1016/s0021-9258(17)43613-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Na--Ca exchange in rat myometrium membrane vesicles highly enriched in plasma membranes1981 · 75 citations
  2. 2Stimulation of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by proteinase pretreatment1982 · 71 citations
  3. 3Effects of pH on Na+-Ca2+ exchange in canine cardiac sarcolemmal vesicles.1982 · 246 citations
  4. 4Na+-Ca2+ exchange is affected by membrane potential in cardiac sarcolemmal vesicles.1980 · 113 citations
  5. 5Na+-Ca2+ exchange in inside-out cardiac sarcolemmal vesicles.1982 · 115 citations