Key result
Dextran plasma expansion increases coronary flow and capillary permeability-surface area products without altering interstitial spaces.
The dilution parameter of flow per unit interstitial space provides a reliable reflection of flow per weight of tissue in the heart without needing a flow probe.
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Offers probe-free dilution metrics for cardiac flow research; leaves open translation of dextran effects to clinical practice.
The effects of coronary flow on cardiac capillary permeability-surface area products and interstitial spaces were examined at rest and after hemodilution in the canine heart. Multiple-indicator-dilution experiments and left atrial injections of microspheres were carried out in closed-chest anesthetized animals at rest and after plasma expansion with dextran. Plasma expansion was utilized to produce a large increase in coronary perfusion compared with control conditions. Values for plasma flow per unit interstitial space, derived from analysis of the indicator-dilution data, were found to correlate closely with average vascular plasma flow per gram, calculated from the cardiac microsphere data; the one reflects the other. With an increase in flow, cardiac capillary permeability-surface area product values were found to increase substantially, whereas the average sucrose extravascular or cardiac interstitial spaces remained stable. Consequently the dilution parameter, flow per unit interstitial space, which is independent of tracer loss, provided a good reflection of flow per weight of tissue in the heart, without the additional requirement for a flow probe.
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Cousineau et al. (1994) studied this question. Plasma expansion with dextran vs. Rest (control conditions) was evaluated on Cardiac capillary permeability-surface area products and interstitial spaces. Plasma expansion with dextran increased coronary flow and cardiac capillary permeability-surface area products, while average cardiac interstitial spaces remained stable.
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