Key result
Increased flow rate caused an increase in capillary permeability surface product and relative interstitial space size, whereas vasodilation at constant flow had no significant effect.
Population
In situ canine heart model
Comparison
Vasodilation at constant flow rate with… vs Control perfusion pressure and flow rate
Design
Preclinical
Authors
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Flow-dependent capillary recruitment may guide microvascular research models; leaves open translation to human coronary physiology.
Capillary recruitment in the coronary microcirculation is driven by increased flow rate rather than vasodilation per se.
Rose et al. (1980) studied in situ canine heart. Vasodilation and increased flow rate vs. Constant basal level was evaluated on Capillary permeability surface (PS) product and interstitial space size. Increased flow rate caused an increase in capillary permeability surface product and relative interstitial space size, whereas vasodilation at constant flow had no significant effect.
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