Key result
Coronary atheroma with 25-50% narrowing fails to impair resting microcirculation versus normal arteries.
Why the study?
The study aimed to quantitate blood flow rate and capillary permeability of 99mTc-DTPA in the human myocardium and assess the influence of small degree atherosclerotic lesions on capillary permeability.
Does the presence of localized coronary atheroma without significant stenosis influence myocardial blood flow rate and capillary permeability of 99mTc-DTPA in patients undergoing coronary angiography?
Comparison
Patients with angiographically normal epicardial coronary arteries vs patients with localized coronary atheroma (25-50% luminal narrowing)
Design
Observational study using intracoronary bolus injection and residue detection
Authors
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No resting microvascular impairment with mild atheroma; leaves open stress-induced or progressive effects.
Observational (n=18)
Does the presence of localized coronary atheroma without significant stenosis influence myocardial blood flow rate and capillary permeability of 99mTc-DTPA in patients undergoing coronary angiography?
Localized coronary atheroma without significant stenosis does not produce measurable dysfunction of the coronary microcirculation in terms of capillary permeability and blood flow rate during resting conditions.
Svendsen et al. (2008) conducted an observational in Uncharacteristic chest pain (n=18). Localized coronary atheroma (25-50% luminal narrowing) vs. Angiographically normal epicardial coronary arteries was evaluated on Capillary permeability-surface area (PS) product of 99mTc-DTPA. Localized coronary atheroma with 25-50% luminal narrowing did not produce measurable dysfunction in coronary microcirculation compared to normal arteries during resting conditions.
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