Key result
In a canine model, 99mTc-Q12 myocardial activity correlated with actual myocardial blood flow (r=0.88, P=0.0001) and showed no evidence of myocardial redistribution up to 4 hours post-injection.
Why the study?
Does 99mTc-Q12 myocardial activity correlate with myocardial blood flow and exhibit redistribution in a canine model of myocardial ischemia?
Population
21 anesthetized, open chest dogs with left circumflex coronary artery occlusion
Design
Preclinical
Follow-up
4 hours
Authors
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Animal data support 99mTc-Q12 as a stable flow tracer; leaves open human translation and trials.
Does 99mTc-Q12 myocardial activity correlate with myocardial blood flow and exhibit redistribution in a canine model of myocardial ischemia?
Effect estimate: r = 0.88
p-value: p=0.0001
In a canine model, 99mTc-Q12 myocardial activity correlates with actual myocardial blood flow up to 2 mL/g/min and shows no evidence of myocardial redistribution over 4 hours.
Gerson et al. (1994) studied Myocardial ischemia (experimental) (n=21). 99mTc-Q12 was evaluated on Relationship between 99mTc-Q12 myocardial activity and actual myocardial blood flow (r = 0.88, p=0.0001). In a canine model, 99mTc-Q12 myocardial activity correlated with actual myocardial blood flow (r=0.88, P=0.0001) and showed no evidence of myocardial redistribution up to 4 hours post-injection.
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