October 1, 1990Circulation

Quantification of area at risk during coronary occlusion and degree of myocardial salvage after reperfusion with technetium-99m methoxyisobutyl isonitrile.

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Why the study?

Does 99mTc-MIBI uptake correlate with occlusion flow and myocardial viability in a canine model of ischemia-reperfusion?

Population

17 open-chest dogs undergoing 3 hours of left anterior descending artery occlusion and 3 hours of reperfusion

Comparison

Technetium-99m methoxyisobutyl isonitrile… vs Correlation with microsphere flow and postmortem…

Design

Preclinical

Follow-up

3 hours of reperfusion

Authors

ASAlbert J. SinusasCardiac Imaging KTKara A TrautmanGustavus Adolphus College JBJames D. BerginUniversity of Virginia

Discussion

Member takes

Implication

Supports timing-dependent 99mTc-MIBI interpretation in experimental ischemia-reperfusion; leaves open clinical translation and validation.

Structured PICO

Does 99mTc-MIBI uptake correlate with occlusion flow and myocardial viability in a canine model of ischemia-reperfusion?

Population

17 open-chest dogs undergoing 3 hours of left anterior descending artery occlusion and 3 hours of reperfusion

Intervention

Technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) injected during occlusion (group 1) or after 90 minutes of reperfusion (group 2)

Comparator

Correlation with microsphere flow and postmortem vital staining

Outcome

Correlation of myocardial 99mTc-MIBI activity with microsphere flow and anatomic risk/infarct areasurrogate

99mTc-MIBI uptake during coronary occlusion reflects the area at risk, whereas uptake after reperfusion reflects myocardial viability rather than the degree of reperfusion.

Cite This Study

Sinusas et al. (1990) studied this question.

synapsesocial.com/papers/6a0f325304e2b0ba896caaae https://doi.org/10.1161/01.cir.82.4.1424

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Implication

Supports timing-dependent 99mTc-MIBI interpretation in experimental ischemia-reperfusion; leaves open clinical translation and validation.

Quantification of area at risk during coronary occlusion and degree of myocardial salvage after reperfusion with technetium-99m methoxyisobutyl isonitrile.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Quantification of area at risk during coronary occlusion and degree of myocardial salvage after reperfusion with technetium-99m methoxyisobutyl isonitrile.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider