February 1, 1999Investigative Radiology

Uptake of Seven Myocardial Tracers During Increased Myocardial Blood Flow by Dobutamine Infusion

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Population

24 open-chest canines with an occluded left-anterior descending coronary artery

Comparison

Thallium-201 and six technetium-99m… vs Direct comparison among the different tracers

Design

Preclinical

Authors

ARAbbe F. RosenbaumUniversity of Cincinnati AMAnthony J. McGoronFlorida International University RMRonald W. MillardUniversity of Cincinnati Medical Center

Discussion

Member takes

Implication

99mTc Q3 merits further tracer development for perfusion imaging; leaves open clinical translation from this canine hyperemia model.

Structured PICO

Population

24 open-chest canines with an occluded left-anterior descending coronary artery

Intervention

Thallium-201 (201TI) and six technetium-99m (99mTc) myocardial-imaging agents (Q3, Q4, Q12, sestamibi, tetrofosmin, N-Noet) during dobutamine infusion

Comparator

Direct comparison among the different tracers

Outcome

Tracer uptake versus myocardial blood flow measured by the radioactive microsphere methodsurrogate

In a canine model with dobutamine-induced hyperemia, the myocardial uptake properties of 99mTc Q3 most closely resembled those of 201TI compared to other 99mTc tracers.

Cite This Study

Rosenbaum et al. (1999) studied this question.

synapsesocial.com/papers/6a9caa542f6d620d5d2efde0 https://doi.org/10.1097/00004424-199902000-00001

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February 1, 1999Investigative Radiology

Uptake of Seven Myocardial Tracers During Increased Myocardial Blood Flow by Dobutamine Infusion

View Full Paper

Ask AI

Bookmark

Population

24 open-chest canines with an occluded left-anterior descending coronary artery

Comparison

Thallium-201 and six technetium-99m… vs Direct comparison among the different tracers

Design

Preclinical

Authors

ARAbbe F. RosenbaumUniversity of Cincinnati AMAnthony J. McGoronFlorida International University RMRonald W. MillardUniversity of Cincinnati Medical Center

Discussion

Member takes

Implication

99mTc Q3 merits further tracer development for perfusion imaging; leaves open clinical translation from this canine hyperemia model.

Structured PICO

Population

24 open-chest canines with an occluded left-anterior descending coronary artery

Intervention

Thallium-201 (201TI) and six technetium-99m (99mTc) myocardial-imaging agents (Q3, Q4, Q12, sestamibi, tetrofosmin, N-Noet) during dobutamine infusion

Comparator

Direct comparison among the different tracers

Outcome

Tracer uptake versus myocardial blood flow measured by the radioactive microsphere methodsurrogate

In a canine model with dobutamine-induced hyperemia, the myocardial uptake properties of 99mTc Q3 most closely resembled those of 201TI compared to other 99mTc tracers.

Cite This Study

Rosenbaum et al. (1999) studied this question.

synapsesocial.com/papers/6a9caa542f6d620d5d2efde0 https://doi.org/10.1097/00004424-199902000-00001

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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