Key result
During adenosine-induced hyperemia in dogs, both 201Tl and 99mTc-sestamibi significantly underestimated flow disparity, with sestamibi showing greater underestimation (P=0.001).
Why the study?
Does 99mTc-sestamibi uptake differ from 201Tl uptake in reflecting coronary flow disparities during adenosine-induced vasodilation in a canine model of coronary stenosis?
Population
22 dogs instrumented with flow transducers on the left anterior descending and circumflex arteries…
Comparison
Simultaneous injection of 201Tl and… vs Comparison between the two tracers and against…
Design
Preclinical
Follow-up
5 minutes
Authors
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May compromise ischemia quantification during adenosine stress; leaves open translation to clinical perfusion imaging.
Does 99mTc-sestamibi uptake differ from 201Tl uptake in reflecting coronary flow disparities during adenosine-induced vasodilation in a canine model of coronary stenosis?
p-value: p=0.001
In a canine model, both 201Tl and 99mTc-sestamibi significantly underestimated the magnitude of flow disparity between stenotic and normal perfusion beds during adenosine-induced hyperemia, with sestamibi showing greater underestimation.
Glover et al. (1995) studied Coronary stenosis (n=22). 99mTc-sestamibi vs. 201Tl was evaluated on Ratio of stenotic to normal activity compared to microsphere-determined flow disparity (p=0.001). During adenosine-induced hyperemia in dogs, both 201Tl and 99mTc-sestamibi significantly underestimated flow disparity, with sestamibi showing greater underestimation (P=0.001).
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