Key result
Adenosine suffusion decreases apparent permeability in isolated pig coronary arterioles by ~35%.
Answers are grounded in this paper and cite their sources.
Adenosine alters arteriole solute permeability independently of its ability to change arteriolar caliber, indicating that coronary exchange capacity reflects both flow and solute permeation.
We have developed a new method to quantify solute flux per unit surface area and concentration gradient (JS/S delta C) from arterioles isolated from pig hearts. The apparent permeability (Ps) was assessed from measurements of JS/S delta C for two proteins, alpha-lactalbumin (alpha-lactalb) and porcine serum albumin (PSA), labeled with the fluorescent dye tetramethylrhodamine isothiocyanate at a mean hydrostatic pressure of 16 +/- 1 cmH2O. Ps for alpha-lactalb (Ps alpha-lactalb) was 16.5 +/- 4.6 x 10(-7) cm/s (mean +/- SE, N = 8 pigs), a value significantly higher than Ps for PSA (PsPSA) (7.1 +/- 1.4 x 10(-7) cm/s, N = 11 pigs, P < 0.05). Suffusion of the arterioles (44 +/- 10 microns diam; n = 48 arterioles) with 10(-5) M adenosine resulted in a 35% decrease in Ps alpha-lactalb and 29% decrease in PsPSA. Data from the present study are consistent with adenosine altering arteriole Js independently from its ability to change arteriolar caliber. One implication of these results is that changes in coronary exchange capacity reflect not only changes in flow through, but also solute permeation from, the microvasculature.
No takes yet. Share an insight, caveat, or question.
Huxley et al. (1996) studied this question. Adenosine vs. Basal state was evaluated on Apparent permeability (Ps) for alpha-lactalbumin and porcine serum albumin. Suffusion of isolated pig coronary arterioles with 10(-5) M adenosine resulted in a 35% decrease in apparent permeability for alpha-lactalbumin and a 29% decrease for porcine serum albumin.
Synapse has enriched 10 related papers. Consider them for comparative context: