Population
Frog (Rana pipiens) mesenteric microvessels
Comparison
100 nM atrial natriuretic peptide or 1 microM… vs Perfusate containing untreated, crystallized BSA
Design
Preclinical
Authors
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Does not inform clinical fluid management; leaves open whether albumin-associated factors regulate microvessel conductance in vivo.
Small hydrophilic albumin-associated substances antagonize AP- and SNP-induced elevations of exchange microvessel hydraulic conductance.
Huxley et al. (1990) studied this question.