Population
81 individually perfused mesenteric capillaries (microvessels) of the frog, Rana pipiens
Comparison
Human atrial natriuretic peptide at… vs Control perfusion with frog Ringer solution…
Design
Preclinical
Authors
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ANP may modulate plasma volume via capillary effects in animals; hypothesis-generating for human fluid homeostasis, requiring validation.
Physiological levels of ANP acutely and reversibly elevate single capillary water conductivity, demonstrating a mechanism by which the peptide may alter plasma volume.
Meyer et al. (1990) studied this question.
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