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February 1, 1992Circulation ResearchOpen Access

Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators.

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Population

Frog mesenteric capillaries

Comparison

Luminal exposure to cGMP-dependent vasodilators… vs Control/basal levels

Design

Preclinical

Authors

DMDenny J. MeyerIDEXX Laboratories (France)VHVirginia H. HuxleyUniversity of Missouri

Discussion

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Implication

cGMP-elevating agents increase capillary hydraulic conductivity in animal vessels; leaves open human microvascular relevance.

Structured PICO

P
Population
Frog mesenteric capillaries
I
Intervention
Luminal exposure to cGMP-dependent vasodilators including atrial natriuretic peptide (ANP), truncated atriopeptins (ANP-I, ANP-III), sodium nitroprusside (SNP), and cGMP phosphodiesterase inhibitor M&B 22948
C
Comparator
Control/basal levels
O
Outcome
Capillary hydraulic conductivity (Lp)surrogate

Agents that elevate cellular cGMP levels mediate an increase in capillary hydraulic conductivity in perfused exchange vessels.

Cite This Study

Meyer et al. (1992) studied this question.

synapsesocial.com/papers/6a7eb2d9cb17bc2d1d0d2687https://doi.org/10.1161/01.res.70.2.382
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential sensitivity of exchange vessel hydraulic conductivity to atrial natriuretic peptide1990 · 26 citations
  2. 2Clearance function of type C receptors of atrial natriuretic factor in rats1989 · 134 citations
  3. 3Effect of atriopeptin III on hematocrit and volemia of nephrectomized rats1986 · 81 citations
  4. 4Capillary permeability: an albumin component attenuates active changes in Lp1990 · 10 citations
  5. 5Atrial natriuretic peptide and nitroprusside cause relaxation of cultured rat mesangial cells1989 · 75 citations