Endothelium increases medial hydraulic conductance of aorta, possibly by release of EDRF

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Structured PICO

Population

Anesthetized New Zealand White rabbits (n=41 total across multiple experiments)

Intervention

L-NAME (inhibitor of EDRF synthesis) and de-endothelialization

Comparator

Control state (absence of L-NAME) and intact endothelium

Outcome

Hydraulic conductance (Lp) of the aorta at different pressures (50 mmHg, 75 mmHg, 125 mmHg)surrogate

Endothelium-derived relaxing factor (EDRF) increases the hydraulic conductance of the rabbit aorta at low pressures.

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These animal findings should not alter clinical practice; they extend mechanistic insights into EDRF but leave human relevance open.

Baldwin et al. (1993) studied this question.

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