Key result
Atrial natriuretic peptide treatment increased skeletal muscle albumin clearance, accounting for at most 30% of the whole body clearance required to regulate plasma volume.
Population
C57BL6 mice; mice with endothelium-restricted deletion of GC-A (floxed GC-A x tie2-Cre: endothelial cell…
Comparison
Atrial natriuretic peptide (ANP) treatment vs Normovolaemic littermates or baseline
Design
Preclinical
Authors
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No immediate change to volume management; extends mechanistic insight into ANP endothelial actions but leaves clinical translation open.
ANP induces small increases in microvascular permeability in skeletal muscle and skin, accounting for a minor portion of the whole-body clearance required for plasma volume regulation.
Curry et al. (2009) studied this question. Atrial natriuretic peptide (ANP) vs. Control littermates / baseline was evaluated on Albumin clearance and microvascular permeability. Atrial natriuretic peptide treatment increased skeletal muscle albumin clearance, accounting for at most 30% of the whole body clearance required to regulate plasma volume.
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