Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 2005Journal of Clinical InvestigationOpen Access

Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide

View Full Paper
Ask AI
Bookmark
Share

Population

Mice with endothelium-restricted deletion of the GC-A gene (EC GC-A KO) and control mice

Comparison

Intravenous infusion of atrial natriuretic peptide vs Control mice

Design

Preclinical

Authors

KSKarim SabraneMKMarkus N. KruseLFLarissa Fabritz

Discussion

Loading...

Member takes

Overview

Does not alter ANP therapies in patients; leaves open endothelial GC-A as a target in human hypertension.

Structured PICO

P
Population
Mice with endothelium-restricted deletion of the GC-A gene (EC GC-A KO) and control mice
I
Intervention
Intravenous infusion of atrial natriuretic peptide (ANP)
C
Comparator
Control mice
O
Outcome
Changes in arterial blood pressure, cardiac hypertrophy, plasma volume, hematocrit, and clearance of radio-iodinated albuminsurrogate

Endothelial GC-A receptors are critically required for the hypovolemic and hypotensive actions of ANP via increases in endothelial permeability.

Cite This Study

Sabrane et al. (2005) studied this question.

synapsesocial.com/papers/6a71466df44fa9f079df0efchttps://doi.org/10.1172/jci23360
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function2000 · 38 citations
  2. 2Guanylyl cyclase mediates ANP-induced vasoconstriction of murine splenic vessels2003 · 17 citations
  3. 3The physiological and pathophysiological modulation of the endocrine function of the heart2001 · 105 citations
  4. 4The physiological and pathophysiological modulation of the endocrine function of the heart2001 · 137 citations
  5. 5Genetic disruption of atrial natriuretic peptide receptor-A alters renin and angiotensin II levels2001 · 68 citations