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May 1, 2008EndocrinologyOpen Access

The Heart Communicates with the Endothelium through the Guanylyl Cyclase-A Receptor: Acute Handling of Intravascular Volume in Response to Volume Expansion

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Why the study?

Does ANP via the GC-A receptor regulate microvascular endothelial macromolecule permeability and intravascular volume in mice?

Population

Mice with endothelial-restricted GC-A deletion, control mice, and cultured lung endothelial cells

Comparison

Atrial natriuretic peptide administration and… vs Control mice

Design

Preclinical

Authors

BSBarbara SchreierUnion Bank of SwitzerlandSBSebastian BörnerUniversity of WürzburgKVKatharina VölkerUniversity of Würzburg

Discussion

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Implication

Supports ANP-GC-A permeability regulation in mice; leaves open translation to human volume homeostasis.

Structured PICO

Does ANP via the GC-A receptor regulate microvascular endothelial macromolecule permeability and intravascular volume in mice?

P
Population
Mice with endothelial-restricted GC-A deletion (EC GC-A KO mice), control mice, and cultured lung endothelial cells
I
Intervention
Atrial natriuretic peptide (ANP) administration (local superfusion 100 nm or intravenous infusion 500 ng/kg x min) and acute vascular volume expansion
C
Comparator
Control mice
O
Outcome
Microvascular permeability to fluorescein isothiocyanate-labeled albumin (BSA), hematocrit, and central venous pressuresurrogate

ANP regulates intravascular volume by enhancing microvascular endothelial macromolecule permeability via the GC-A receptor.

Cite This Study

Schreier et al. (2008) studied this question.

synapsesocial.com/papers/6a88fb1903fab2a419a5eac8https://doi.org/10.1210/en.2008-0212
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physiological Role of Silent Receptors of Atrial Natriuretic Factor1987 · 940 citations
  2. 2Atrial Natriuretic Peptide as a Regulator of Transvascular Fluid Balance1996 · 35 citations
  3. 3Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide2005 · 171 citations
  4. 4Atrial natriuretic peptide: an essential physiological regulator of transvascular fluid, protein transport, and plasma volume2005 · 94 citations
  5. 5The physiological and pathophysiological modulation of the endocrine function of the heart2001 · 105 citations