Key result
Preparative ultracentrifugation yields mixed LDL and HDL rather than a unique class versus gel filtration.
The 1.040-1.063 g/ml density interval of bovine lipoproteins isolated by ultracentrifugation contains a mixture of low and high density lipoproteins, not a unique class.
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Ultracentrifugation density fractions may mix lipoprotein classes in bovine models; leaves optimal isolation methods open for lipid research.
Grummer et al. (1983) studied this question. Preparative ultracentrifugation vs. Gel filtration chromatography was evaluated on Lipoprotein elution profiles and composition. Preparative ultracentrifugation yielded a 1.040-1.063 g/ml density fraction that was a mixture of low and high density lipoproteins, rather than a unique class, compared to gel filtration.
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