Key result
ICR mice exhibit higher auricular ANP granules and content than other strains despite similar blood pressure.
p-value: p=<0.001
Requires strain standardization in murine ANP studies; leaves open effects on systemic regulation or human translation.
Atrial (A-type) natriuretic peptide (ANP) is vasodilative hormone involved in the regulation of blood pressure and volume homeostasis. In this study, we examined the differences of the auricular and plasma ANP distribution by immunohistochemistry, ultrastructural morphometry, and radioimmunoassay in five strains of mice. The ANP-immunoreactivities of the auricle were most intense in ICR, and moderate in C57BL/6J and C3H/HeN, and weakest in BALB/cA and DBA/2Cr. The number of ANP-granules was greatest in ICR followed by C57BL, C3H or BALB/c, and DBA/2 mice, in this order. The auricular ANP content was highest in ICR, but the plasma ANP concentration was comparable in all strains. The present study demonstrates that there are differences in the ANP circulating system between five strains.
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Mifune et al. (2011) studied Healthy (strain differences) (n=25). Mouse strain (ICR, C57BL/6J, C3H/HeN, BALB/cA, DBA/2Cr) was evaluated on Number of auricular ANP-granules and auricular ANP concentration (p=<0.001). The number of auricular ANP-granules and auricular ANP content were significantly highest in ICR mice compared to other strains, despite comparable plasma ANP concentrations and blood pressure.
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