Key result
Ibuprofen matches or outperforms indomethacin but equals or trails paracetamol for preterm PDA closure.
Why the study?
The study was conducted to systematically review ibuprofen, including versus indomethacin and paracetamol/acetaminophen, for the closure of patent ductus arteriosus.
Does ibuprofen improve the closure of patent ductus arteriosus in preterm infants compared to indomethacin or paracetamol?
Population
Seven meta-analyses evaluating patent ductus arteriosus closure in preterm infants
Comparison
Ibuprofen vs indomethacin and paracetamol/acetaminophen
Design
Systematic review of published meta-analyses
Authors
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Favors ibuprofen over indomethacin for preterm PDA closure; confirms comparative efficacy while leaving optimal paracetamol positioning open.
Systematic Review (n=7)
Does ibuprofen improve the closure of patent ductus arteriosus in preterm infants compared to indomethacin or paracetamol?
Oral ibuprofen appears more effective than IV ibuprofen for PDA closure in preterm infants and has safety advantages over indomethacin, though evidence is limited by methodological heterogeneity.
Al‐Shaibi et al. (2021) conducted a systematic review in patent ductus arteriosus (n=7). Ibuprofen vs. indomethacin and paracetamol/acetaminophen was evaluated on closure of patent ductus arteriosus. Ibuprofen is equivalent or superior to indomethacin and inferior or equivalent to paracetamol for the closure of patent ductus arteriosus in preterm infants.
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